N-Methyl-D-Aspartic Acid (NMDA)

Other Name: N-Methyl-D-Aspartic Acid; NMDA; N-methyl-D-aspartate
CAS No.: 6384-92-5
Molecular Formula: C5H9NO4
Molecular Weight: 147.130
Appearance: White Powder
Specifications: 99%

Function
NMDA selectively activates NMDA receptors, which are ionotropic receptors permeable to calcium ions (Ca²⁺). These receptors are critical for synaptic plasticity, learning, and memory.

Description About N-Methyl-D-Aspartic Acid (NMDA)
N-Methyl-D-Aspartic Acid (NMDA) is a significant neurotransmitter receptor agonist belonging to the ionotropic subfamily of glutamate receptors. It plays a pivotal role within the central nervous system, participating in processes such as learning, memory, and neural plasticity. Activation of the NMDA receptor requires the simultaneous binding of both glutamate and glycine, as well as the depolarization of the cell membrane to relieve the blocking effect of magnesium ions. Dysfunctional activity of this receptor is implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. In the realm of scientific research, NMDA receptors and their ligands are widely utilized to investigate the mechanisms underlying neurodegenerative diseases and to explore potential therapeutic strategies. Furthermore, the NMDA receptor is involved in pain perception and synaptic plasticity, serving as an essential tool in neuroscience research.