Phloretin

Source: Apple tree leaves
Other Name: Phloretin; Dihydronaringenin; Phloretol
CAS NO.: 60-82-2
Molecular Formula: C15H14O5
Molecular Weight: 274.27
Appearance: White to Beige Powder
Purity: 95%,98%,99%

Function
1. It effectively scavenges free radicals and reduces oxidative stress, thereby protecting cells from damage.
2. It alleviates inflammatory conditions by inhibiting key enzymes and signaling pathways involved in the inflammatory response.
3. It helps enhance vascular elasticity, lower blood pressure, and reduce the risk of cardiovascular disease.
4. It may inhibit tumor growth and metastasis by promoting apoptosis (programmed cell death) in cancer cells.
5. It boosts immune function, helping the body defend against infections and diseases.
6. It supports healthy blood sugar levels and helps combat the progression of diabetes.
7. By improving blood circulation, it helps alleviate leg fatigue and symptoms associated with varicose veins.
8. It helps maintain youthful-looking skin and improves overall skin health by reducing inflammation and oxidative stress.

Applications
1. Food Additives:
As a natural bitterness inhibitor, phloretin can be incorporated into products such as beverages and gummies to enhance their flavor profile. It effectively suppresses bitterness and other off-flavors in food products, while also mitigating the off-tastes associated with high-intensity sweeteners; it yields even better results when used in combination with sweeteners such as stevia.
2. Health Supplements:
Phloretin possesses potential biological activities—including antioxidant, anti-inflammatory, hypoglycemic, and anti-tumor properties—and is primarily utilized in the development of health-related products.
3. Pharmaceutical Research:
As a natural inhibitor of glucose transporters, phloretin is employed in research related to diabetes and its associated complications.

Description About Phloretin
Phloretin is a natural active ingredient extracted from the peels and root bark of succulent fruits such as apples and pears. In the fields of cosmetics and health supplements, phloretin serves as an effective agent for skin whitening and anti-aging. Furthermore, phloretin acts as a unique natural bitterness inhibitor and flavor modifier; it can suppress bitterness and other off-flavors in food products, thereby improving palatability. It also helps mitigate the off-tastes associated with high-intensity sweeteners and masks their undesirable flavors. Given its versatility, phloretin can be widely incorporated into various products—including beverages, tablets, and soft candies—and holds immense market potential.
Research has revealed that phloretin possesses a wide range of pharmacological properties, including antioxidant, anti-tumor, anti-inflammatory, and immunosuppressive effects, as well as the ability to promote bone formation. Additionally, it offers numerous cosmetic benefits, such as delaying skin aging, whitening the complexion, reducing inflammation, and treating acne.
Phloretin exhibits potent antioxidant activity, with an effective antioxidant concentration for oils ranging between 10 and 30 ppm; it effectively scavenges free radicals within the skin. Its antioxidant mechanism primarily relies on the chelation of metal ions via its polyhydroxyl structure, thereby significantly inhibiting lipid peroxidation and protecting cells from oxidative damage. As a flavonoid compound, phloretin scavenges free radicals, mitigates oxidative damage induced by ultraviolet (UV) radiation, protects collagen and elastic fibers, and ultimately delays the skin aging process.
Phloretin inhibits the activity of alpha-glucosidase, thereby delaying the breakdown of carbohydrates into glucose and helping to regulate postprandial blood glucose levels. Animal studies have also demonstrated its ability to reduce triglyceride and cholesterol levels in the bloodstream.
In vitro studies indicate that phloretin can induce apoptosis (programmed cell death) in cancer cells and inhibit tumor angiogenesis. It has demonstrated inhibitory effects against various cancer cell lines—including those associated with breast cancer and colon cancer—though further clinical trials are required to validate these findings.