Orlistat

CAS NO.: 96829-58-2
Molecular Formula: C29H53NO5
Molecular Weight: 495.745
Appearance: White Powder
Purity: ≥98.0%

Function
1. Inhibits fat absorption
By selectively inhibiting gastrointestinal lipase activity, it prevents the breakdown of approximately one-third of dietary fat into absorbable free fatty acids and monoacylglycerols; the undigested fat is then excreted from the body. This mechanism reduces caloric intake and is suitable for obese patients who have not achieved satisfactory results through dietary control alone.
2. Aids in weight loss
It helps obese patients lose weight and is particularly effective for obesity characterized by visceral fat accumulation.
3. Improves lipid metabolism
It lowers serum total cholesterol and low-density lipoprotein (LDL) cholesterol levels, offering a dual regulatory effect for obese patients with comorbid hyperlipidemia.
4. Controls blood glucose fluctuations
For obese patients with type 2 diabetes, orlistat can moderately improve insulin sensitivity and help lower glycated hemoglobin (HbA1c) levels. Its mechanism of action is linked to weight loss and the reduction of the toxic effects of free fatty acids on pancreatic beta cells.

Description About Orlistat
Orlistat is a weight-loss medication classified as a gastrointestinal lipase inhibitor; it aids in weight loss by inhibiting fat absorption. By suppressing the activity of enzymes in the intestine that break down fat, it reduces the absorption of dietary fat by approximately 30%, thereby lowering caloric intake. It is indicated for adult patients with a BMI of 30 or higher, or a BMI of 27 or higher accompanied by obesity-related conditions (such as hypertension or diabetes).
Orlistat functions primarily by inhibiting pancreatic lipase activity, thereby preventing the breakdown of dietary triglycerides into absorbable free fatty acids and monoacylglycerols. The undigested fat is excreted directly through the digestive tract, resulting in reduced caloric intake. By blocking the body's absorption of dietary fat and lowering calorie intake, Orlistat facilitates weight loss while simultaneously reducing health risks associated with obesity.