MOG (35-55)

Other Name.: Myelin Oligodendrocyte Glycoprotein Peptide (35-55)
CAS NO.: 163913-87-9
Appearance: White Powder
Purity: ≥98%

Function
1. Induces an experimental autoimmune encephalomyelitis (EAE) model;
2. Specifically activates CD4+ T cells, inducing their proliferation and attacking the myelin sheath, leading to demyelinating lesions;
3. Inhibits the spontaneous regeneration of dopaminergic neurons after MPTP injury, suggesting that it may affect neural repair through immune mechanisms;
4. Increases the proportion of regulatory T cells (Tregs) and inhibits pathogenic CD8+ T cells, providing a new approach for the treatment of neuroinflammatory diseases;

Description About MOG (35-55)
MOG (35-55) has some water solubility, dissolving in water with a solubility of approximately 0.5-1 mg/ml. Due to its high content of hydrophobic amino acids, it also exhibits some hydrophobicity. It has a high isoelectric point and typically carries a positive charge in solution.
MOG (35-55) is a specific peptide derived from the MOG protein, which is primarily associated with the myelin sheath in the central nervous system. This peptide has gained attention in research related to multiple sclerosis (MS) and other neurological conditions because it plays a role in the immune response and can serve as an antigen.
MOG (35-55) is crucial for the stability and integrity of myelin sheaths, which insulate nerve fibers.
MOG (35-55) can induce an autoimmune response, making it a focus of study in MS, where the body mistakenly attacks its own myelin.
It is commonly used in experimental models to study demyelination and to test potential therapies aimed at modulating the immune response.