Glimepiride

CAS No.: 93479-97-1
Molecular Formula: C24H34N4O5S
Molecular Weight: 490.62
Appearance: White Powder
Purity (HPLC): ≥98.0%

Advantages
1. Rapid blood glucose-lowering effect; particularly suitable for patients with newly diagnosed Type 2 diabetes who still retain some pancreatic function;
2. Inexpensive and convenient to take orally; widely used in primary care settings and by the majority of patients in my country;
3. Milder than first- and second-generation sulfonylureas, with relatively less impact on the cardiovascular system.

Function
1. Promotes insulin secretion: Acts directly on pancreatic beta cells to increase insulin release.
2. Improves insulin resistance: Enhances the sensitivity of tissues—such as muscle and adipose tissue—to insulin.
3. Long-acting blood glucose lowering: Maintains stable blood glucose levels and offers high treatment adherence.

Application
It is indicated for type 2 diabetes mellitus in patients whose blood glucose levels cannot be adequately controlled by diet, exercise, and weight loss.

Description About Glimepiride
Glimepiride is primarily used for blood glucose control in patients with type 2 diabetes. It functions by stimulating pancreatic beta cells to release insulin and by improving the sensitivity of peripheral tissues to insulin. Its primary therapeutic effect is lowering blood glucose levels in type 2 diabetes patients by stimulating the pancreas to secrete more insulin.
The main action of glimepiride is stimulating pancreatic beta cells to secrete insulin, which is the core mechanism behind its blood glucose-lowering effect. Additionally, it may assist in lowering blood glucose by enhancing the sensitivity of peripheral tissues to insulin.